Cytotoxic T-lymphocyte Immunotherapy for Ovarian Cancer

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

cytotoxic t lymphocyte associated molecule -4 (ctla-4) gene polymorphisms in ovarian cancer patients

background: ovarian cancer is a relatively common cancer among postmenopausal women. nowadays, there is controversy about immunotherapy of ovarian cancer patients with interleukins such as interferon to reach better out come in prognosis of patients under chemotherapy. ctla-4 is a gene, which has an important role in homeostasis and regulation of immune response. inhibitory nature of ctla-4 is ...

متن کامل

Adoptive immunotherapy by avidin-driven cytotoxic T lymphocyte-tumor bridging.

We have shown previously that T cells, tagged with biotinylated anti-CD3 antibody fragments, can exert avidin-dependent cytolytic activity on suitably biotinylated tumor cells in vitro. In this study, we demonstrate that avidin-driven CTL-tumor bridging in vivo leads to growth inhibition of murine tumors WEHI-164 fibrosarcoma and RMA lymphoma. The biodistribution of biotin-tagged 111In-labeled ...

متن کامل

Chitosan thermogels for local T lymphocyte delivery for cancer immunotherapy

Background The success of systemic adoptive T cell transfer lies in the capacity of the antigen-experienced cytotoxic T lymphocytes to access and persist within the tumour microenvironment. The mimicking of tertiary lymphoid structures that promote a protective immune response against cancer can be achieved using an injectable biocompatible matrix that releases anti-tumour, proliferating T lymp...

متن کامل

T lymphocyte engineering with cytokine nanogels for enhanced cancer immunotherapy

Background Adoptive cell transfer (ACT) with autologous tumorreactive T cells is a promising strategy in cancer immunotherapy, but treatment of solid tumors is limited by the rapid decline in function of the transplanted T cells. In order to maintain high numbers of viable antigen-specific cytotoxic T cells in tumors, co-administration of supporting immunostimulant agents together with transfer...

متن کامل

Activated cytotoxic T-lymphocyte immunotherapy is effective for advanced oral and maxillofacial cancers.

Conventional cancer treatments are surgery, radiotherapy, and chemotherapy, but treatment efficiency is insufficient and cancer recurrence is common. Immunotherapy has been added as an important cancer treatment component, but no reports on its efficacy in oral and maxillofacial cancers exist. We evaluated the clinical efficacy of adoptive immunotherapy using ex vivo-activated cytotoxic T lymph...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Immunotherapy

سال: 2012

ISSN: 1524-9557

DOI: 10.1097/cji.0b013e318243f213